ACETYLCHOLINESTERASE ACTIVITY OF SCHISTOSOMA MANSONI*
نویسندگان
چکیده
منابع مشابه
Imatinib activity on Schistosoma mansoni
Imatinib, a drug used for treatment of human chronic myeloid leukaemia, due to its activity against protein kinases, has been also evaluated in vitro against Schistosoma mansoni showing high schistosomicidal activity. In the present experiments imatinib activity in vitro was confirmed at the doses of 25 µM, 50 µM and 100 µM. The first drug activity observed with the lower dose was interruption ...
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A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice for schistosomiasis. Though the S enantiomer and the metabolites are presumed to contribute only a little to the activity of the drug, in-depth side-by-side studies are lacking. The aim of this study was to investigate the in vitro activities of PZQ and its main metabolites, namely, R- and S-cis-...
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a Departamento de Bioquı́mica Médica, Uni6ersidade Federal do Rio de Janeiro, Cidade Uni6ersitária, 21941-590, Rio de Janeiro, RJ, Brazil b Di6isão de Quı́mica, Setor de Quı́mica Orgânica, CENPES, Petrobrás, Cidade Uni6ersitária, 21949-900, Rio de Janeiro, RJ, Brazil c Centro de Biociências e Biotecnologia, Uni6ersidade Estadual do Norte Fluminense, Campos dos Goytacazes, RJ, 28015-620, Brazil d I...
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(1)Institute of Tropical Medicine, São Paulo, SP, Brasil. (2)Division of Nephrology, “Hospital das Clinicas”, University of S. Paulo, Medical School, S. Paulo, SP, Brasil. (3)São Paulo Federal University Medical School, Dept. of Microbiology, Immunology, and Parasitology, S. Paulo, SP, Brazil. Correspondence to: Dr. Thales De Brito, Av. Dr. Enéas de Carvalho Aguiar 470, 05403–000 S. Paulo, SP, ...
متن کاملActivity of praziquantel on in vitro transformed Schistosoma mansoni sporocysts.
Praziquantel (PZQ) is effective against all the evolutive phases of Schistosoma mansoni. Infected Biomphalaria glabrata snails have their cercarial shedding interrupted when exposed to PZQ. Using primary in vitro transformed sporocysts, labeled with the probe Hoechst 33258 (indicator of membrane integrity), and lectin of Glycine max (specific for carbohydrate of N-acetylgalactosamine membrane),...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1952
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1952.tb00722.x